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重组人血红素加氧酶1(HO

时间:2021-07-15 来源:eisar.com.cn 作者:月夜星空文库网

  本品由我们的大肠杆菌表达系统制备而成,目的基因编码的Met1-Thr261表达纯化得来。

  HO-1/HMOX1/HSP32质量控制:>95%(还原性SDS-PAGE)

  HO-1/HMOX1/HSP32制剂:液体

  HO-1/HMOX1/HSP32保存:收到货后请置于-20℃,可保存6个月,避免反复冻融。

  关于HO-1/HMOX1/HSP32:

  Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues.

  相关搜索:重组人血红素加氧酶1(HO-1)(HMOX1)(HSP32),Recombinant Human Heme Oxygenase 1

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